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The Present State of the Hyperthermia in Japan,and by What Kind of Way Should We Progress from Now on?
https://doi.org/10.20558/00001202
https://doi.org/10.20558/00001202ef5373ba-8dea-4f0c-a09e-afd42d104cb3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2 (1.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-08-03 | |||||
| タイトル | ||||||
| タイトル | The Present State of the Hyperthermia in Japan,and by What Kind of Way Should We Progress from Now on? | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 温熱療法 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 化学療法 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NF-kB | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 上皮間葉移行 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 免疫療法 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | hyperthermia | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | chemotherapy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | NF-kB | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Epithelial-Mesenchymal Transition | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | immunotherapy | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.20558/00001202 | |||||
| ID登録タイプ | JaLC | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | 日本のがん治療におけるハイパーサーミアの現状と今後の展望 | |||||
| 著者 |
古倉, 聡
× 古倉, 聡 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hyperthermia has a long history as a treatment modality for tumors, with the rapid development of heating devices for hyperthermia starting more than a century ago. Ideal heating devices would enable the targeted area to be heated in accordance with the depth and width of the tumor. However, hyperthermia alone does not show attractive results for cancer patients, but does appear to reinforce many therapeutic options, especially against for liver cancer. Hyperthermia is a potent sensitizer for radiotherapy, chemotherapy, and immune therapy, each of which has significantly advanced in this decade. A multimodal treatment approach that relies on hyperthermia combined with state-of-the-art radiation, chemotherapy, and immune therapy can result in great clinical benefits for pancreatic cancer patients. In a prior study, we demonstrated that hyperthermia enhances the cytotoxicity of gemcitabine, one of the key drugs for pancreatic cancer, by inhibiting gemcitabine -induced activation of nuclear factor kappa B (NF-kB). Considering these results, combining hyperthermia and chemotherapy could result in better treatment outcomes for pancreatic cancer patients. Hyperthermia may reduce the metastatic potential of cancer cells and inhibit tumor metastasis. However, the underlying mechanisms through which hyperthermia inhibits cancer metastasis have yet to be fully elucidated. Epithelial-to-mesenchymal transition (EMT) plays a key role in tumor metastasis; therefore, we investigated and summarized the effects and underlying mechanisms of EMT in cancer cells. The results suggest that hyperthermia not only inhibits tumor growth, but also mediates the expression of EMT-related genes̶including E-cadherin and vimentin. Elevated body temperature has been thought to play an important role in the regulation of immune responses, and accumulating evidence in thermal medicine indicates that hyperthermia could be a useful combination therapy to enhance the efficacy of cancer immunotherapy. I believe that, in the years to come, a stronger focus on the research and development of these novel yet safe modals is what is required for a treatment breakthrough to emerge that ultimately results in longer survival and higher quality of life for many cancer patients. |
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| 書誌情報 |
ja : 京都学園大学健康医療学部紀要 号 1, p. 13-19, 発行日 2016-03-31 |
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| 出版者 | ||||||
| 出版者 | 京都学園大学健康医療学部研究会 | |||||
| 言語 | ja | |||||
