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Global gene expression analysis in the liver of mice administered carcinogens and non-carcinogens For the development of a new rapid and reliable carcinogenicity test
https://doi.org/10.20558/00001187
https://doi.org/10.20558/00001187abf2eebd-07f9-411b-bfa3-012c92e4aa09
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
13-19 (932.0 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-05 | |||||
| タイトル | ||||||
| タイトル | Global gene expression analysis in the liver of mice administered carcinogens and non-carcinogens For the development of a new rapid and reliable carcinogenicity test | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 発がん性 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | DNA マイクロアレイ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 網羅的遺伝子発現解析 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 予測 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 発がん物質 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | carcinogenicity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | DNA microarray | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | global gene expression analysis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | prediction | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | carcinogens | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.20558/00001187 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
古倉, 聡
× 古倉, 聡× 高木, 智久× 水島, かつら |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although much has been elucidated about the mechanism of cellular carcinogenesis, evaluation of the carcinogenicity of substances is still difficult. Since a number of new synthetic materials for drugs and food have been developed, it is necessary to sufficiently evaluate their carcinogenicities. In carcinogenicity tests performed at present, the test substance is administered to rodents for 2 years (their life span) and its carcinogenicity in each organ is evaluated by macroscopic and pathological examinations. Such carcinogenicity tests require considerable time and resources. In this study, we attempted to develop a new carcinogenicity test by global gene expression analysis, which is independent of target organ-specific activity of carcinogens. All food and chemicals are primarily transported to the liver via the portal vein, both of which are independent of the routes of intake. Therefore, we selected the liver as the best organ with which to assess carcinogenicity in gene expression analysis. The present report indicates the possibility that global gene analysis by using DNA microarray in the liver 3 hours after the administration of chemicals could establish a rapid bioassay to identify carcinogens for various organs. |
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| 言語 | en | |||||
| 書誌情報 |
京都学園大学健康医療学部紀要 号 2, p. 13-19, 発行日 2017-03-28 |
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| 出版者 | ||||||
| 出版者 | 京都学園大学健康医療学部研究会 | |||||
| 言語 | ja | |||||
